| Title : Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase - Khoobi_2013_Eur.J.Med.Chem_68C_291 |
| Author(s) : Khoobi M , Alipour M , Moradi A , Sakhteman A , Nadri H , Razavi SF , Ghandi M , Foroumadi A , Shafiee A |
| Ref : Eur Journal of Medicinal Chemistry , 68C :291 , 2013 |
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Abstract :
Novel hybrid derivatives of two known scaffolds; tetrahydroaminoquinoline and coumarin were synthesized and evaluated for both acetylcholinesterase (AChE) and butyrylcholinesterase (BCHE) activities. By means of an efficient nanocatalyst, the reaction time for the syntheses of the target compounds was reduced. Subsequently, Ellman's modified method was used to evaluate the enzyme inhibitory activity of the synthesized structures. It was observed that most hybrid structures were moderate to potent inhibitors of AChE compared to Tacrine as the reference drug among which 7f with 4-fluorophenyl substituent was the most active compound (IC50 = 5 nM). |
| PubMedSearch : Khoobi_2013_Eur.J.Med.Chem_68C_291 |
| PubMedID: 23988412 |
Khoobi M, Alipour M, Moradi A, Sakhteman A, Nadri H, Razavi SF, Ghandi M, Foroumadi A, Shafiee A (2013)
Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase
Eur Journal of Medicinal Chemistry
68C :291
Khoobi M, Alipour M, Moradi A, Sakhteman A, Nadri H, Razavi SF, Ghandi M, Foroumadi A, Shafiee A (2013)
Eur Journal of Medicinal Chemistry
68C :291