| Title : The Arg473Cys-neuroligin-1 mutation modulates NMDA mediated synaptic transmission and receptor distribution in hippocampal neurons - Khosravani_2005_FEBS.Lett_579_6587 |
| Author(s) : Khosravani H , Altier C , Zamponi GW , Colicos MA |
| Ref : FEBS Letters , 579 :6587 , 2005 |
| Abstract : Synapses mediate communication between neurons, thus playing a fundamental role in information processing in the CNS. Neuroligins form a family of heterophilic synaptic cell adhesion molecules, and neuroligin 1 (NL1) has been shown to be involved in the formation of excitatory synapses and have been suggested to associate indirectly with NMDA receptors by common binding to PSD95. A mutation in neuroligin 3 (Arg451Cys-NL3, human sequence numbering) identified in autistic patients is associated with altered spine density and has reduced binding capacity for its presynaptic partner beta-neurexin. Here, we investigated the role of NL1 and the homologous NL1 mutation Arg473Cys-NL1 (R473C-NL1) in excitatory synaptic transmission and NMDA receptor distribution. We demonstrate that R473C-NL1, when expressed in cultured hippocampal neurons, can induce a dramatic increase in NMDA current amplitude and that this change is accompanied by NMDA receptor clustering in the postsynaptic cell. |
| ESTHER : Khosravani_2005_FEBS.Lett_579_6587 |
| PubMedSearch : Khosravani_2005_FEBS.Lett_579_6587 |
| PubMedID: 16298368 |
Khosravani H, Altier C, Zamponi GW, Colicos MA (2005)
The Arg473Cys-neuroligin-1 mutation modulates NMDA mediated synaptic transmission and receptor distribution in hippocampal neurons
FEBS Letters
579 :6587
Khosravani H, Altier C, Zamponi GW, Colicos MA (2005)
FEBS Letters
579 :6587