| Title : Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity - Kihara_1998_Brain.Res_792_331 |
| Author(s) : Kihara T , Shimohama S , Urushitani M , Sawada H , Kimura J , Kume T , Maeda T , Akaike A |
| Ref : Brain Research , 792 :331 , 1998 |
|
Abstract :
We examined the effects of nicotinic receptor agonists against beta amyloid (Abeta) cytotoxicity to rat cortical neurons. Administration of nicotine protected against Abeta-induced neuronal death. This neuroprotection was blocked by dihydro-beta-erythroidine, an alpha4beta2 nicotinic receptor antagonist. Furthermore, incubation with cytisine, a selective alpha4beta2 nicotinic receptor agonist, inhibited Abeta cytotoxicity. These results suggest that alpha4beta2 nicotinic receptor activation plays an important role in neuroprotection against Abeta cytotoxicity. |
| PubMedSearch : Kihara_1998_Brain.Res_792_331 |
| PubMedID: 9593977 |
Kihara T, Shimohama S, Urushitani M, Sawada H, Kimura J, Kume T, Maeda T, Akaike A (1998)
Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity
Brain Research
792 :331
Kihara T, Shimohama S, Urushitani M, Sawada H, Kimura J, Kume T, Maeda T, Akaike A (1998)
Brain Research
792 :331