| Title : Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase - Kihara_2023_Biosci.Biotechnol.Biochem__ |
| Author(s) : Kihara Y , Nishimura E , Kanai C , Kitano Y , Suzuki E , Hasumi K |
| Ref : Biosci Biotechnol Biochem , : , 2023 |
|
Abstract :
Soluble epoxide hydrolase (EC 3.3.2.10) is a key enzyme in the regulation of inflammation and metabolism, whereas the role of its N-terminal phosphatase activity (N-phos) has been poorly understood because of a lack of selective inhibitors. Here we report 4-aminobenzoic (Ki 15.3 microM) and 3-amino-4-hydroxy benzoic acid (Ki 11.7 microM) as selective competitive inhibitors of N-phos. |
| PubMedSearch : Kihara_2023_Biosci.Biotechnol.Biochem__ |
| PubMedID: 36758967 |
Kihara Y, Nishimura E, Kanai C, Kitano Y, Suzuki E, Hasumi K (2023)
Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase
Biosci Biotechnol Biochem
:
Kihara Y, Nishimura E, Kanai C, Kitano Y, Suzuki E, Hasumi K (2023)
Biosci Biotechnol Biochem
: