| Title : Increase by NO synthase inhibitors of acetylcholine release from guinea-pig myenteric plexus - Kilbinger_1994_Naunyn.Schmiedebergs.Arch.Pharmacol_349_543 |
| Author(s) : Kilbinger H , Wolf D |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 349 :543 , 1994 |
|
Abstract :
The effects of nitric oxide (NO) synthase inhibitors on the electrically evoked release of [3H]acetylcholine were studied in guinea-pig myenteric plexus preparations preincubated with [3H]choline. NG-monomethyl-L-arginine (EC50 5.3 mumol l-1) and NG-nitro-L-arginine (EC50 1.3 mumol l-1) concentration-dependently increased the evoked release of [3H]acetylcholine without affecting the basal outflow. The facilitatory effect of NG-mono-methyl-L-arginine was prevented by L-arginine but not by D-arginine. The results suggest that endogenous NO inhibits the depolarisation-evoked release of acetylcholine. |
| PubMedSearch : Kilbinger_1994_Naunyn.Schmiedebergs.Arch.Pharmacol_349_543 |
| PubMedID: 7520537 |
Kilbinger H, Wolf D (1994)
Increase by NO synthase inhibitors of acetylcholine release from guinea-pig myenteric plexus
Naunyn Schmiedebergs Arch Pharmacol
349 :543
Kilbinger H, Wolf D (1994)
Naunyn Schmiedebergs Arch Pharmacol
349 :543