Killam_1984_Fed.Proc_43_2510

Reference

Title : Evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon - Killam_1984_Fed.Proc_43_2510
Author(s) : Killam EK , Killam KF, Jr.
Ref : Federation Proceedings , 43 :2510 , 1984
Abstract :

The experimental evidence that indicates that alterations in neurotransmitter activity exacerbate or diminish seizure responses to intermittent light stimulation in the Papio papio model of epilepsy is reviewed. Studies of the effects of drugs known to modify the synthesis, storage release, or activity of known or putative neurotransmitters are included. Catecholamines, to a lesser extent the indolamine, serotonin, and the inhibitory transmitter gamma-aminobutyric acid all alter seizures as do less well understood intrinsic hormones and pentapeptides. The anticonvulsant profile of the model is briefly reviewed. It is concluded that there is as yet no concrete evidence of an intrinsic deficit in any of the neurotransmitters to which the genetic photosensitivity of this model can be attributed.

PubMedSearch : Killam_1984_Fed.Proc_43_2510
PubMedID: 6145626

Related information

Citations formats

Killam EK, Killam KF, Jr. (1984)
Evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon
Federation Proceedings 43 :2510

Killam EK, Killam KF, Jr. (1984)
Federation Proceedings 43 :2510