| Title : Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase - Kim_2002_Arch.Pharm.Res_25_817 |
| Author(s) : Kim DK |
| Ref : Arch Pharm Res , 25 :817 , 2002 |
|
Abstract :
In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive. |
| PubMedSearch : Kim_2002_Arch.Pharm.Res_25_817 |
| PubMedID: 12510831 |
Kim DK (2002)
Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase
Arch Pharm Res
25 :817
Kim DK (2002)
Arch Pharm Res
25 :817