| Title : Acetylcholinesterase inhibitors from the roots of Angelica dahurica - Kim_2002_Arch.Pharm.Res_25_856 |
| Author(s) : Kim DK , Lim JP , Yang JH , Eom DO , Eun JS , Leem KH |
| Ref : Arch Pharm Res , 25 :856 , 2002 |
|
Abstract :
In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots of Angelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three furanocoumarins, isoimperatorin (1), imperatorin (2) and oxypeucedanin (3), as active principles. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1-3 were 74.6, 63.7 and 89.1 microM, respectively. |
| PubMedSearch : Kim_2002_Arch.Pharm.Res_25_856 |
| PubMedID: 12510838 |
Kim DK, Lim JP, Yang JH, Eom DO, Eun JS, Leem KH (2002)
Acetylcholinesterase inhibitors from the roots of Angelica dahurica
Arch Pharm Res
25 :856
Kim DK, Lim JP, Yang JH, Eom DO, Eun JS, Leem KH (2002)
Arch Pharm Res
25 :856