| Title : Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase - Kim_2003_Arch.Pharm.Res_26_735 |
| Author(s) : Kim DK , Lee K |
| Ref : Arch Pharm Res , 26 :735 , 2003 |
|
Abstract :
The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-coumaroyl tyramine, as an inhibitor on AChE. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of trans-N-p-coumaroyl tyramine was 34.5 microg/mL (122 microM). |
| PubMedSearch : Kim_2003_Arch.Pharm.Res_26_735 |
| PubMedID: 14560923 |
Kim DK, Lee K (2003)
Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase
Arch Pharm Res
26 :735
Kim DK, Lee K (2003)
Arch Pharm Res
26 :735