| Title : Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator - Kim_2007_Bioorg.Med.Chem.Lett_17_4855 |
| Author(s) : Kim JS , Padnya A , Weltzin M , Edmonds BW , Schulte MK , Glennon RA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :4855 , 2007 |
|
Abstract :
Desformylflustrabromine (dFBr; 1) and desformylflustrabromine-B (dFBr-B; 2) have been previously isolated from natural sources, and the former has been demonstrated to be a novel and selective positive allosteric modulator of alpha4beta2 nicotinic acetylcholine (nACh) receptors. The present study describes the synthesis of water-soluble salts of 1 and 2, and confirms and further investigates the actions of 1 and 2 using two-electrode voltage clamp recordings. |
| PubMedSearch : Kim_2007_Bioorg.Med.Chem.Lett_17_4855 |
| PubMedID: 17604168 |
Kim JS, Padnya A, Weltzin M, Edmonds BW, Schulte MK, Glennon RA (2007)
Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator
Bioorganic & Medicinal Chemistry Lett
17 :4855
Kim JS, Padnya A, Weltzin M, Edmonds BW, Schulte MK, Glennon RA (2007)
Bioorganic & Medicinal Chemistry Lett
17 :4855