| Title : Highly enantioselective dynamic kinetic resolution of 1,2-diarylethanols by a lipase-ruthenium couple - Kim_2008_Org.Lett_10_1295 |
| Author(s) : Kim MJ , Choi YK , Kim S , Kim D , Han K , Ko SB , Park J |
| Ref : Org Lett , 10 :1295 , 2008 |
|
Abstract :
A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols. This procedure employs a highly enantioselective lipase from Pseudomonas stutzeri (trade name, lipase TL) as the resolution catalyst and a ruthenium complex as the racemization catalyst. Sixteen 1,2-diarylethanols have been efficiently resolved to provide their acetyl derivatives with good yields (95-97%) and high enantiomeric excesses (96-99%). |
| PubMedSearch : Kim_2008_Org.Lett_10_1295 |
| PubMedID: 18303906 |
Kim MJ, Choi YK, Kim S, Kim D, Han K, Ko SB, Park J (2008)
Highly enantioselective dynamic kinetic resolution of 1,2-diarylethanols by a lipase-ruthenium couple
Org Lett
10 :1295
Kim MJ, Choi YK, Kim S, Kim D, Han K, Ko SB, Park J (2008)
Org Lett
10 :1295