Title : (-)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase - Kim_2016_Int.J.Biol.Macromol_91_1033 |
Author(s) : Kim JH , Lee SH , Lee HW , Sun YN , Jang WH , Yang SY , Jang HD , Kim YH |
Ref : Int J Biol Macromol , 91 :1033 , 2016 |
Abstract :
Cholinesterase inhibitors block the bioconversion of neurotransmitters by cholinesterase in the nervous system. Epicatechin derivatives (1, 3 and 5), polyphenols (6 and 7) from Orostachys japonicus, and catechin derivatives (2 and 4) from our in-house library were evaluated for their inhibitory activity on cholinesterase. Compound 5 exhibited IC50 values of 58.3+/-2.4 and 17.8+/-3.8mug/mL on AChE and BuChE, respectively. Compound 5 inhibited BuChE more strongly than AChE through a competitive behavior. In silico binding positions of 5 in the active site were predicted using Autodock 4.2 and processed in a 10000-ps molecular dynamics simulation to assess the stability of compound 5 binding. |
PubMedSearch : Kim_2016_Int.J.Biol.Macromol_91_1033 |
PubMedID: 27341781 |
Inhibitor | Epicatechin-gallate |
Substrate | Epicatechin-gallate |
Kim JH, Lee SH, Lee HW, Sun YN, Jang WH, Yang SY, Jang HD, Kim YH (2016)
(-)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase
Int J Biol Macromol
91 :1033
Kim JH, Lee SH, Lee HW, Sun YN, Jang WH, Yang SY, Jang HD, Kim YH (2016)
Int J Biol Macromol
91 :1033