Kim_2018_Molecules_23_

Reference

Title : DPP-IV Inhibitory Potentials of Flavonol Glycosides Isolated from the Seeds of Lens culinaris: In Vitro and Molecular Docking Analyses - Kim_2018_Molecules_23_
Author(s) : Kim BR , Kim HY , Choi I , Kim JB , Jin CH , Han AR
Ref : Molecules , 23 : , 2018
Abstract :

Dipeptidyl peptidase IV (DPP-IV), a new target for the treatment of type 2 diabetes mellitus, degrades incretins such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide. DPP-IV inhibitors shorten the inactivation of GLP-1, permitting the incretin to stimulate insulin release, thereby combating hyperglycemia. In our ongoing search for new DPP-IV inhibitors from medicinal plants and foods, three flavonol glycosides (1(-)3) were isolated from the seeds of Lens culinaris Medikus (Fabaceae) and tested for their DPP-IV(-)inhibitory activity. We demonstrated for the first time, that compounds 1(-)3 inhibited DPP-IV activity in a concentration-dependent manner in our in vitro bioassay system. In addition, molecular docking experiments of compounds 1(-)3 within the binding pocket of DPP-IV were conducted. All investigated compounds readily fit within the active sites of DPP-IV, in low-energy conformations characterized by the flavone core structure having optimal electrostatic attractive interactions with the catalytic triad residues of DPP-IV.

PubMedSearch : Kim_2018_Molecules_23_
PubMedID: 30103438

Related information

Citations formats

Kim BR, Kim HY, Choi I, Kim JB, Jin CH, Han AR (2018)
DPP-IV Inhibitory Potentials of Flavonol Glycosides Isolated from the Seeds of Lens culinaris: In Vitro and Molecular Docking Analyses
Molecules 23 :

Kim BR, Kim HY, Choi I, Kim JB, Jin CH, Han AR (2018)
Molecules 23 :