Title : Evaluating the Memory Enhancing Effects of Angelica gigas in Mouse Models of Mild Cognitive Impairments - Kim_2019_Nutrients_12_ |
Author(s) : Kim M , Song M , Oh HJ , Hui J , Bae W , Shin J , Ji SD , Koh YH , Suh JW , Park H , Maeng S |
Ref : Nutrients , 12 : , 2019 |
Abstract :
(1) Background: By 2050, it is estimated that 130 million people will be diagnosed with dementia, and currently approved medicines only slow the progression. So preventive intervention is important to treat dementia. Mild cognitive impairment is a condition characterized by some deterioration in cognitive function and increased risk of progressing to dementia. Therefore, the treatment of mild cognitive impairment (MCI) is a possible way to prevent dementia. Angelica gigas reduces neuroinflammation, improves circulation, and inhibits cholinesterase, which can be effective in the prevention of Alzheimer's disease and vascular dementia and the progression of mild cognitive impairment. (2) Methods: Angelica gigas (AG) extract 1 mg/kg was administered to mildly cognitive impaired mice, models based on mild traumatic brain injury and chronic mild stress. Then, spatial, working, and object recognition and fear memory were measured. (3) Result: Angelica gigas improved spatial learning, working memory, and suppressed fear memory in the mild traumatic brain injury model. It also improved spatial learning and suppressed cued fear memory in the chronic mild stress model animals. (4) Conclusions: Angelica gigas can improve cognitive symptoms in mild cognitive impairment model mice. |
PubMedSearch : Kim_2019_Nutrients_12_ |
PubMedID: 31905851 |
Kim M, Song M, Oh HJ, Hui J, Bae W, Shin J, Ji SD, Koh YH, Suh JW, Park H, Maeng S (2019)
Evaluating the Memory Enhancing Effects of Angelica gigas in Mouse Models of Mild Cognitive Impairments
Nutrients
12 :
Kim M, Song M, Oh HJ, Hui J, Bae W, Shin J, Ji SD, Koh YH, Suh JW, Park H, Maeng S (2019)
Nutrients
12 :