Kiraly_2011_Eur.J.Pharmacol_650_195

Reference

Title : The dipeptidyl peptidase IV (CD26, EC 3.4.14.5) inhibitor vildagliptin is a potent antihyperalgesic in rats by promoting endomorphin-2 generation in the spinal cord - Kiraly_2011_Eur.J.Pharmacol_650_195
Author(s) : Kiraly K , Lambeir AM , Szalai J , Szentirmay A , Luyten W , Barna I , Puskar Z , Kozsurek M , Ronai AZ
Ref : European Journal of Pharmacology , 650 :195 , 2011
Abstract :

We have reported previously that the dipeptidyl peptidase IV inhibitor Ile-Pro-Ile had an antihyperalgesic action in rats when given intrathecally in the carrageenan-induced hyperalgesia, as detected by the Randall-Selitto test. Vildagliptin, a non-peptide inhibitor of the same enzyme, which is already on the market as an "euglycemic" agent in diabetics, has a slightly more potent and more sustained antihyperalgesic effect in the same test when given by the same route. The action of 3nmol/rat vildagliptin could be antagonized by subcutaneous naltrexone (0.5mg/kg) pretreatment, or by intrathecally co-administered specific antiserum to endomorphin-2. Thus, the antihyperalgesia by vildagliptin, similarly to Ile-Pro-Ile, was opioid receptor-mediated and could be attributed to the promotion of endomorphin-2 generation in rat spinal cord dorsal horn. Furthermore, vildagliptin (1mg/kg) is a potent antihyperalgesic also when given subcutaneously.

PubMedSearch : Kiraly_2011_Eur.J.Pharmacol_650_195
PubMedID: 20940010

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Citations formats

Kiraly K, Lambeir AM, Szalai J, Szentirmay A, Luyten W, Barna I, Puskar Z, Kozsurek M, Ronai AZ (2011)
The dipeptidyl peptidase IV (CD26, EC 3.4.14.5) inhibitor vildagliptin is a potent antihyperalgesic in rats by promoting endomorphin-2 generation in the spinal cord
European Journal of Pharmacology 650 :195

Kiraly K, Lambeir AM, Szalai J, Szentirmay A, Luyten W, Barna I, Puskar Z, Kozsurek M, Ronai AZ (2011)
European Journal of Pharmacology 650 :195