Kitt_1984_Science_226_1443

Reference

Title : Evidence for cholinergic neurites in senile plaques - Kitt_1984_Science_226_1443
Author(s) : Kitt CA , Price DL , Struble RG , Cork LC , Wainer BH , Becher MW , Mobley WC
Ref : Science , 226 :1443 , 1984
Abstract :

In the neocortices and amygdalae of young and aged macaques, cholinergic axons were identified by means of a monoclonal antibody to bovine choline acetyltransferase. Many fine, linear, immunoreactive profiles were seen in these animals. In the older animals, some cholinergic axons showed multifocal enlargements along their course. In some instances, neurites with choline acetyltransferase immunoreactivity were associated with deposits of amyloid (visualized with thioflavin T fluorescence). The appearance of these amyloid-associated abnormal cholinergic processes was similar to that of neurites in senile plaques, as shown by conventional silver impregnation techniques. Cholinergic systems thus give rise to some of the neurites within senile plaques.

PubMedSearch : Kitt_1984_Science_226_1443
PubMedID: 6505701

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Citations formats

Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC (1984)
Evidence for cholinergic neurites in senile plaques
Science 226 :1443

Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC (1984)
Science 226 :1443