| Title : Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates - Kitt_1985_Neurosci_16_691 |
| Author(s) : Kitt CA , Struble RG , Cork LC , Mobley WC , Walker LC , Joh TH , Price DL |
| Ref : Neuroscience , 16 :691 , 1985 |
|
Abstract :
Immunocytochemical studies, using a polyclonal antibody directed against tyrosine hydroxylase, identified catecholaminergic axons in prefrontal cortex of young and aged nonhuman primates. Aged monkeys, who showed cortical senile plaques in silver stains, had swollen tyrosine hydroxylase-immunoreactive axons in neocortex. Some of these abnormal processes were associated with deposits of amyloid (visualized by thioflavin-T fluorescence) and were similar in appearance to neurites demonstrated by silver impregnation methods. This study provides evidence for structural abnormalities in catecholaminergic axons/nerve terminals in the neocortices of aged primates. |
| PubMedSearch : Kitt_1985_Neurosci_16_691 |
| PubMedID: 2869445 |
Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL (1985)
Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates
Neuroscience
16 :691
Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL (1985)
Neuroscience
16 :691