Title : Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa - Klein-Junior_2020_J.Nat.Prod__ |
Author(s) : Klein-Junior LC , Cretton S , Vander Heyden Y , Gasper AL , Nejad-Ebrahimi S , Christen P , Henriques AT |
Ref : Journal of Natural Products , : , 2020 |
Abstract :
Phytochemical investigation of the alkaloid extract of the aerial parts of Psychotria nemorosa led to the isolation and characterization of 10 azepine-indole alkaloids, i.e., cimitrypazepine (1), fargesine (2), nemorosines A (3), and B (12), nemorosinosides A-F (4-9), as well as two beta-carboline derivatives, 10-hydroxyisodolichantoside (10) and 10-hydroxydolichantoside (11), an isoxazole alkaloid, nemorosinoside G (13), serotonin (14), bufotenine (15), and (S)-gentianol (16). Compounds 3-13 have not yet been described. These compounds were isolated by semipreparative HPLC, and their structures were determined by means of HRMS, NMR, and ECD measurements. In addition, the monoamine oxidase-A (MAO-A), MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities were evaluated. Alkaloids 1-3 inhibited the MAO-A activity with IC50 values of 1.4, 1.4, and 0.9 muM, respectively. |
PubMedSearch : Klein-Junior_2020_J.Nat.Prod__ |
PubMedID: 32150413 |
Klein-Junior LC, Cretton S, Vander Heyden Y, Gasper AL, Nejad-Ebrahimi S, Christen P, Henriques AT (2020)
Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa
Journal of Natural Products
:
Klein-Junior LC, Cretton S, Vander Heyden Y, Gasper AL, Nejad-Ebrahimi S, Christen P, Henriques AT (2020)
Journal of Natural Products
: