| Title : Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease - Kogen_2002_Org.Lett_4_3359 |
| Author(s) : Kogen H , Toda N , Tago K , Marumoto S , Takami K , Ori M , Yamada N , Koyama K , Naruto S , Abe K , Yamazaki R , Hara T , Aoyagi A , Abe Y , Kaneko T |
| Ref : Org Lett , 4 :3359 , 2002 |
|
Abstract :
Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. Both compounds showed potent inhibitory activities against AChE and SERT. [structure: see text] |
| PubMedSearch : Kogen_2002_Org.Lett_4_3359 |
| PubMedID: 12323018 |
Kogen H, Toda N, Tago K, Marumoto S, Takami K, Ori M, Yamada N, Koyama K, Naruto S, Abe K, Yamazaki R, Hara T, Aoyagi A, Abe Y, Kaneko T (2002)
Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease
Org Lett
4 :3359
Kogen H, Toda N, Tago K, Marumoto S, Takami K, Ori M, Yamada N, Koyama K, Naruto S, Abe K, Yamazaki R, Hara T, Aoyagi A, Abe Y, Kaneko T (2002)
Org Lett
4 :3359