Komek_2021_Mol.Imaging.Radionucl.Ther_30_201

A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwent (18)flourine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for staging. The tumor was located in the superior external quadrant of the right breast, and did not exhibit pathological uptake in (18)F-FDG PET/CT. Later, gallium-(68) ((68)Ga) fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT imaging was performed and the primary tumor showed intense radiotracer accumulation. This presumes that (68)Ga-FAPI PET/CT imaging is superior to (18)F-FDG imaging in detecting the primary tumor in breast cancer, thereby suggesting the replacement of FAPI by (18)F-FDG in breast-cancer staging in the future.