Kondo_2007_Bioorg.Med.Chem_15_2631

Reference

Title : Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration - Kondo_2007_Bioorg.Med.Chem_15_2631
Author(s) : Kondo T , Nekado T , Sugimoto I , Ochi K , Takai S , Kinoshita A , Tajima Y , Yamamoto S , Kawabata K , Nakai H , Toda M
Ref : Bioorganic & Medicinal Chemistry , 15 :2631 , 2007
Abstract :

A series of 5beta-methylprolyl-2-cyanopyrrolidine analogs were synthesized and evaluated as DPP-IV inhibitors, and the duration of their ex vivo activity was assessed. Comparison of their potency and duration of action was done among three different species. The mode of binding was investigated, and the effect on the plasma glucose level was evaluated. Structure-activity relationships are also presented.

PubMedSearch : Kondo_2007_Bioorg.Med.Chem_15_2631
PubMedID: 17293118

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Citations formats

Kondo T, Nekado T, Sugimoto I, Ochi K, Takai S, Kinoshita A, Tajima Y, Yamamoto S, Kawabata K, Nakai H, Toda M (2007)
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration
Bioorganic & Medicinal Chemistry 15 :2631

Kondo T, Nekado T, Sugimoto I, Ochi K, Takai S, Kinoshita A, Tajima Y, Yamamoto S, Kawabata K, Nakai H, Toda M (2007)
Bioorganic & Medicinal Chemistry 15 :2631