| Title : Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration - Kondo_2007_Bioorg.Med.Chem_15_2631 |
| Author(s) : Kondo T , Nekado T , Sugimoto I , Ochi K , Takai S , Kinoshita A , Tajima Y , Yamamoto S , Kawabata K , Nakai H , Toda M |
| Ref : Bioorganic & Medicinal Chemistry , 15 :2631 , 2007 |
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Abstract :
A series of 5beta-methylprolyl-2-cyanopyrrolidine analogs were synthesized and evaluated as DPP-IV inhibitors, and the duration of their ex vivo activity was assessed. Comparison of their potency and duration of action was done among three different species. The mode of binding was investigated, and the effect on the plasma glucose level was evaluated. Structure-activity relationships are also presented. |
| PubMedSearch : Kondo_2007_Bioorg.Med.Chem_15_2631 |
| PubMedID: 17293118 |
Kondo T, Nekado T, Sugimoto I, Ochi K, Takai S, Kinoshita A, Tajima Y, Yamamoto S, Kawabata K, Nakai H, Toda M (2007)
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration
Bioorganic & Medicinal Chemistry
15 :2631
Kondo T, Nekado T, Sugimoto I, Ochi K, Takai S, Kinoshita A, Tajima Y, Yamamoto S, Kawabata K, Nakai H, Toda M (2007)
Bioorganic & Medicinal Chemistry
15 :2631