Konishi_2012_Pharmacology_91_86

Reference

Title : Donepezil Abolishes Anticholinergic Activity in a Patient with Amnesia - Konishi_2012_Pharmacology_91_86
Author(s) : Konishi K , Hori K , Tomioka H , Minegishi G , Tani M , Tanaka H , Akita R , Yokoyama S , Oshio T , Hachisu M
Ref : Pharmacology , 91 :86 , 2012
Abstract :

We report the case of a 74-year-old woman who presented with amnesia and positive serum anticholinergic activity (SAA), which disappeared after treatment with the cholinesterase inhibitor donepezil for 1 year. Her only other regular medications were topical glaucoma preparations. We suggest that mental stress, mild cognitive impairment and Alzheimer's disease pathology combined to generate SAA in this patient. We also consider that SAA may have subsequently become negative because of upregulation of acetylcholine production by donepezil, and because the patient's other medications and physical condition (including glaucoma) remained unchanged during the 1-year period.

PubMedSearch : Konishi_2012_Pharmacology_91_86
PubMedID: 23258422

Related information

Citations formats

Konishi K, Hori K, Tomioka H, Minegishi G, Tani M, Tanaka H, Akita R, Yokoyama S, Oshio T, Hachisu M (2012)
Donepezil Abolishes Anticholinergic Activity in a Patient with Amnesia
Pharmacology 91 :86

Konishi K, Hori K, Tomioka H, Minegishi G, Tani M, Tanaka H, Akita R, Yokoyama S, Oshio T, Hachisu M (2012)
Pharmacology 91 :86