| Title : NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response - Kopf_2001_Brain.Res_894_141 |
| Author(s) : Kopf SR , Benton RS , Kalfin R , Giovannini MG , Pepeu G |
| Ref : Brain Research , 894 :141 , 2001 |
|
Abstract :
We investigated in rats the effect N(G)-nitro-L-arginine methyl ester (L-NAME) on retention of a passive avoidance response, and cortical ACh release monitored using the microdialysis technique. Post-training administration of L-NAME impaired 24 h retention of a passive avoidance and decreased cortical ACh release. Both effects of L-NAME were reversed by L-Arg. These results suggest that nitric oxide is involved in retention of the passive avoidance response through the modulation of the forebrain cholinergic system. |
| PubMedSearch : Kopf_2001_Brain.Res_894_141 |
| PubMedID: 11245824 |
Kopf SR, Benton RS, Kalfin R, Giovannini MG, Pepeu G (2001)
NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response
Brain Research
894 :141
Kopf SR, Benton RS, Kalfin R, Giovannini MG, Pepeu G (2001)
Brain Research
894 :141