Korkmaz_2023_Chem.Biodivers__e202300038

In this study, the biological activity of the silver coordination compound K-22 was investigated. The IC50 values of K-22 on cancer cell lines range from 0.797 microg/mL to 3.426 microg/mL, indicating that K-22 might preferably inhibit A549, Saos-2, MCF-7, and HT-29 cell proliferation and thus have better therapeutic activity. Furthermore, K-22 stimulated apoptosis via up-regulation of the mRNA and protein expression level of Bax/Bcl-2 ratio in A549, Saos-2, MCF-7, and HT-29. K-22 exhibited antimicrobial activity against S. aureus, E. faecalis, K. pneumonia, P. aeruginosa, C. utilis and C. albicans. Experimental results show that the compound has inhibitory potential with an IC50 value of 178.10 microM for the BChE (butyrylcholinesterase) enzyme, which has a vital role in the progression of Alzheimer's disease. As a result, compound K-22 exhibits a strong potential for medical use due to its anticancer, antibacterial, antifungal, and anti-alzheimer's properties.