Kosower_1983_FEBS.Lett_163_161

Reference

Title : A hypothesis for the mechanism of sodium channel opening by batrachotoxin and related toxins - Kosower_1983_FEBS.Lett_163_161
Author(s) : Kosower EM
Ref : FEBS Letters , 163 :161 , 1983
Abstract :

The mechanism of action of one class of sodium channel opening agents (batrachotoxin, veratridine, aconitine and grayanotoxin) is proposed to involve complexation of a triad of agent oxygen atoms with the epsilon-ammonium ion of a channel lysing side chain, holding open the mouth or exit of the ion channel. This idea complements the oxygen triad model derived by structural considerations (Masutani, T., Seyama, I., Narahashi, T. and Iwasa, J. (1981) J. Pharm. Exp. Therap. 217, 812) and extended by crystal structure comparisons (Codding, P.W. (1983) J. Am. Chem. Soc. 105, 3172). The mechanism is based on results for acetylcholine receptor ion channel gating, structure and function, using single group rotation (SGR) theory (cf. Kosower, E.M. (1983) Biochem. Biophys. Res. Commun. 111, 1022 and in press (1983); FEBS Lett. (1983) 155, 245; ibid. 157, 144; Biophys. J. (1983) 45, in press).

PubMedSearch : Kosower_1983_FEBS.Lett_163_161
PubMedID: 6315483

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Citations formats

Kosower EM (1983)
A hypothesis for the mechanism of sodium channel opening by batrachotoxin and related toxins
FEBS Letters 163 :161

Kosower EM (1983)
FEBS Letters 163 :161