Title : Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects: different association patterns in subjects with type 2 diabetes mellitus - Kotani_2010_Diabetol.Metab.Syndr_2_50 |
Author(s) : Kotani K , Kimura S , Ebara T , Caccavello R , Gugliucci A |
Ref : Diabetol Metab Syndr , 2 :50 , 2010 |
Abstract :
BACKGROUND:
Aspirin esterase (AE) activity can account for part of aspirin pharmacokinetics in the circulation, possibly being associated with the impairment of aspirin effectiveness as an inhibitor of platelet aggregation.
AIMS:
The study was aimed at investigating the correlations of serum AE activity with cholinesterase (ChE) and metabolic variables in healthy subjects in comparison to subjects with type 2 diabetes mellitus (T2DM).
METHODS:
In cardiovascular disease-free T2DM subjects and healthy controls, the AE activity levels and/or the correlation patterns between AE and the other variables were analyzed.
RESULTS:
Neither AE nor ChE activities were higher in the subjects with T2DM. Serum AE activity strongly correlated with ChE as well as glucose/lipids variables such as total cholesterol and triglyceride in healthy subjects, while the correlations between AE and glucose/lipids variables were not present in T2DM subjects.
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PubMedSearch : Kotani_2010_Diabetol.Metab.Syndr_2_50 |
PubMedID: 20659351 |
Substrate | Aspirin |
Kotani K, Kimura S, Ebara T, Caccavello R, Gugliucci A (2010)
Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects: different association patterns in subjects with type 2 diabetes mellitus
Diabetol Metab Syndr
2 :50
Kotani K, Kimura S, Ebara T, Caccavello R, Gugliucci A (2010)
Diabetol Metab Syndr
2 :50