Koukouli_2015_Biochem.Pharmacol_97(4)_378

Reference

Title : The multiple roles of the alpha7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system - Koukouli_2015_Biochem.Pharmacol_97(4)_378
Author(s) : Koukouli F , Maskos U
Ref : Biochemical Pharmacology , 97 :378 , 2015
Abstract :

Neuronal nicotinic acetylcholine receptors (nAChRs) play an important role in a variety of modulatory and regulatory processes including neurotransmitter release and synaptic transmission in various brain regions of the central nervous system (CNS). Glutamate is the principal excitatory neurotransmitter in the brain and the glutamatergic system participates in the pathophysiology of several neuropsychiatric disorders. Underpinning the importance of nAChRs, many studies demonstrated that nAChRs containing the alpha7 subunit facilitate glutamate release. Here, we review the currently available body of experimental evidence pertaining to alpha7 subunit containing nAChRs in their contribution to the modulation of glutamatergic neurotransmission, and we highlight the role of alpha7 in synaptic plasticity, the morphological and functional maturation of the glutamatergic system and therefore its important contribution in the modulation of neural circuits of the CNS.

PubMedSearch : Koukouli_2015_Biochem.Pharmacol_97(4)_378
PubMedID: 26206184

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Citations formats

Koukouli F, Maskos U (2015)
The multiple roles of the alpha7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system
Biochemical Pharmacology 97 :378

Koukouli F, Maskos U (2015)
Biochemical Pharmacology 97 :378