Koul_2012_Pediatr.Neurol_47_209

Reference

Title : Rituximab in severe seronegative juvenile myasthenia gravis: review of the literature - Koul_2012_Pediatr.Neurol_47_209
Author(s) : Koul R , Al Futaisi A , Abdwani R
Ref : Pediatr Neurol , 47 :209 , 2012
Abstract :

Myasthenia gravis is an autoimmune neuromuscular disorder caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction. A wide range of symptomatic therapy with acetylcholinesterase inhibitors and immunotherapy such as corticosteroids, azathioprine, cyclosporine, mycophenolate mofetil, plasmapheresis, and intravenous immunoglobulin has been used in the treatment of myasthenia gravis, with variable responses. However, most modalities of treatment involve delayed onset of action. We describe a child with severe, life-threatening seronegative myasthenia gravis who repeatedly failed extubation and responded dramatically to rituximab. She achieved complete and sustained remission for more than 9 months, with gradual reduction in steroid dose without any side effects. Advances in the treatment of myasthenia gravis have reduced mortality and morbidity and improved the quality of life in these patients.

PubMedSearch : Koul_2012_Pediatr.Neurol_47_209
PubMedID: 22883288

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Citations formats

Koul R, Al Futaisi A, Abdwani R (2012)
Rituximab in severe seronegative juvenile myasthenia gravis: review of the literature
Pediatr Neurol 47 :209

Koul R, Al Futaisi A, Abdwani R (2012)
Pediatr Neurol 47 :209