| Title : Post-tetanic potentiation at an identified synapse in Aplysia is correlated with a Ca2+-activated K+ current in the presynaptic neuron: evidence for Ca2+ accumulation - Kretz_1982_Proc.Natl.Acad.Sci.U.S.A_79_5430 |
| Author(s) : Kretz R , Shapiro E , Kandel ER |
| Ref : Proc Natl Acad Sci U S A , 79 :5430 , 1982 |
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Abstract :
We have examined the presynaptic changes underlying post-tetanic potentiation (PTP) in Aplysia by using voltage-clamp techniques combined with specific pharmacological blocking agents. The amplitude and time course of PTP parallel a slow outward clamp current that we have identified as a Ca2+-activated K+ current. Because this current is proportional to intracellular Ca2+ concentration our findings provide evidence for the "residual Ca2+ hypothesis," according to which PTP is caused by the accumulation of intracellular Ca2+ after tetanus. To obtain further evidence for this mechanism we injected EGTA intracellularly and found that it decreased the duration of both PTP and the Ca2+ -activated K+ current. |
| PubMedSearch : Kretz_1982_Proc.Natl.Acad.Sci.U.S.A_79_5430 |
| PubMedID: 6291044 |
Kretz R, Shapiro E, Kandel ER (1982)
Post-tetanic potentiation at an identified synapse in Aplysia is correlated with a Ca2+-activated K+ current in the presynaptic neuron: evidence for Ca2+ accumulation
Proc Natl Acad Sci U S A
79 :5430
Kretz R, Shapiro E, Kandel ER (1982)
Proc Natl Acad Sci U S A
79 :5430