| Title : Electrophysiological evidence for multiple glycinergic inputs to neonatal rat sympathetic preganglionic neurons in vitro - Krupp_1997_Eur.J.Neurosci_9_1711 |
| Author(s) : Krupp J , Bordey A , Feltz P |
| Ref : European Journal of Neuroscience , 9 :1711 , 1997 |
| Abstract : The time pattern of glycinergic inhibitory postsynaptic currents (IPSCs) in sympathetic preganglionic neurons was studied in thin transverse spinal cord slices of neonatal (1-10 days postnatal) rats by means of the patchclamp technique. Three time patterns could be distinguished: (i) large events [mostly > 400 pA (30-36 degrees C)] occurring at regular intervals, (ii) small events occurring at irregular intervals, and (iii) small events occurring in transient (1.5-10 s), high-frequency (> 15 Hz) bursts of synaptic activity. The large regular events had uniform kinetics which was consistent with the idea of a proximal site of origin for all of these events. They were reversibly inhibited in amplitude and frequency by extracellular application of a high concentration of acetylcholine (200 microM) or the specific nicotinic acetylcholine receptor agonist dimethylphenylpiperazinium iodide (DMPP; 1 mM), but unaffected by glutamate (100 microM). IPSCs occurring in bursts had slower and less uniform kinetics, suggesting a more diverse site of origin. The frequency of events decreased during a burst. Similar bursts could be induced by extracellular application of glutamate receptor agonists. These results indicate that sympathetic pregnanglionic neurons in a thin, transverse spinal cord slice receive at least two different glycinergic inputs. |
| ESTHER : Krupp_1997_Eur.J.Neurosci_9_1711 |
| PubMedSearch : Krupp_1997_Eur.J.Neurosci_9_1711 |
| PubMedID: 9283825 |
Krupp J, Bordey A, Feltz P (1997)
Electrophysiological evidence for multiple glycinergic inputs to neonatal rat sympathetic preganglionic neurons in vitro
European Journal of Neuroscience
9 :1711
Krupp J, Bordey A, Feltz P (1997)
European Journal of Neuroscience
9 :1711