Title : Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth - Kubinova_2014_J.Enzyme.Inhib.Med.Chem_29_749 |
Author(s) : Kubinova R , Porizkova R , Navratilova A , Farsa O , Hanakova Z , Bacinska A , Cizek A , Valentova M |
Ref : J Enzyme Inhib Med Chem , 29 :749 , 2014 |
Abstract :
Abstract Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7beta,6beta-dihydroxyroyleanone (2), 7beta-acetoxy-6beta-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and alpha-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alpha-glucosidase with IC50 values from 33 to 275 muM. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis. |
PubMedSearch : Kubinova_2014_J.Enzyme.Inhib.Med.Chem_29_749 |
PubMedID: 24506206 |
Kubinova R, Porizkova R, Navratilova A, Farsa O, Hanakova Z, Bacinska A, Cizek A, Valentova M (2014)
Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
J Enzyme Inhib Med Chem
29 :749
Kubinova R, Porizkova R, Navratilova A, Farsa O, Hanakova Z, Bacinska A, Cizek A, Valentova M (2014)
J Enzyme Inhib Med Chem
29 :749