| Title : Synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives - Kumar_2008_J.Enzyme.Inhib.Med.Chem_23_462 |
| Author(s) : Kumar CS , Vinaya K , Chandra JN , Thimmegowda NR , Prasad SB , Sadashiva CT , Rangappa KS |
| Ref : J Enzyme Inhib Med Chem , 23 :462 , 2008 |
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Abstract :
A series of novel substituted 1-benzhydryl-piperazine sulfonamide 8(a-f) and benzamides 9(a-h) were synthesized and their antimicrobial activities evaluated in vitro by paper disc diffusion and micro dilution method against standard strains of Gram-positive (Staphylococcus aureus ATCC 25953, Staphylococcus epidermis 25212, Bacillus cereus 11778, Bacillus substilis 6051) and Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 2853, Proteus vulgaris ATCC 2853 and Salmonella typhi ATCC 9484) bacteria. Among the synthesized new compounds 8d, 8e, 9c, 9e, 9f and 9 h showed potent antimicrobial activities compared to the standard drug streptomycin. |
| PubMedSearch : Kumar_2008_J.Enzyme.Inhib.Med.Chem_23_462 |
| PubMedID: 18608768 |
Kumar CS, Vinaya K, Chandra JN, Thimmegowda NR, Prasad SB, Sadashiva CT, Rangappa KS (2008)
Synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives
J Enzyme Inhib Med Chem
23 :462
Kumar CS, Vinaya K, Chandra JN, Thimmegowda NR, Prasad SB, Sadashiva CT, Rangappa KS (2008)
J Enzyme Inhib Med Chem
23 :462