Kumar_2025_Food.Chem_492_145583

Schizophyllum commune, also known as split-gill mushroom, is an edible fungus with significant medicinal and culinary value. This review explores the bioactive compounds, health benefits, and applications based on research from the last decade. Mushrooms like S. commune are rich in polysaccharides, flavonoids, saponins, and ergosterol, contributing to their antioxidant, antibacterial, antiviral, anti-inflammatory, and immunomodulatory properties. These compounds suggest potential in preventing and managing chronic diseases such as cancer, cardiovascular issues, diabetes, and neurodegenerative conditions. S. commune shows strong antioxidant activity, protecting cells from oxidative stress and DNA damage. It also demonstrates genoprotective and organoprotective effects, particularly against environmental toxins like Bisphenol A. Apart from medicinal use, S. commune acts have applications in pharmaceuticals, functional foods, and nutraceuticals, with notable antibacterial and anticancer effects. It is safe for consumption with no toxicity at high doses and it also offers potential in liver protection, metabolic disorders, and immune health.