Kutty_1977_Experientia_33_420

Human serum beta-lipoproteins isolated by percipitation with heparin-calcium mixture showed cholinesterase activity The enzyme activity was almost proportional to the lipoprotein concentration Rats treated with neostigmine a cholinesterase inhibitor showed a significant decrease in serum beta-lipoprotein and in the incorporation of H3-lysine into the lipoprotein compared to untreated controls The decreased incorporation of H3-lysine into beta-lipoprotein was associated with increased labelling of alpha-lopoprotein There was no significant difference in the labelling of pre-beta-lipoprotein We propose that LDL is formed from VLDL in the presence of cholinesterase