| Title : Identification and characterization of KvgAS, a two-component system in Klebsiella pneumoniae CG43 - Lai_2003_FEMS.Microbiol.Lett_218_121 |
| Author(s) : Lai YC , Lin GT , Yang SL , Chang HY , Peng HL |
| Ref : FEMS Microbiology Letters , 218 :121 , 2003 |
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Abstract :
A two-component system encoding gene cluster kvgAS that is present only in virulent Klebsiella pneumoniae CG43 was isolated and its sequence determined. RT-PCR and Southern analysis demonstrated that kvgAS is organized as an operon. No apparent effect of a kvgS deletion on bacterial virulence was observed in a mouse peritonitis model. In the presence of paraquat or 2,2-dipyridyl, the activity of kvgAS promoter in the kvgS mutant was found to be reduced to half of the level in the wild-type strain. The data suggest that the KvgAS system is autoregulated and plays a role in countering free radical stresses and sensing iron-limiting conditions. |
| PubMedSearch : Lai_2003_FEMS.Microbiol.Lett_218_121 |
| PubMedID: 12583907 |
| Gene_locus related to this paper: klepn-q4w4d0 |
| Gene_locus | klepn-q4w4d0 |
Lai YC, Lin GT, Yang SL, Chang HY, Peng HL (2003)
Identification and characterization of KvgAS, a two-component system in Klebsiella pneumoniae CG43
FEMS Microbiology Letters
218 :121
Lai YC, Lin GT, Yang SL, Chang HY, Peng HL (2003)
FEMS Microbiology Letters
218 :121