Lauderback_1999_Life.Sci_65_1977

Reference

Title : Amyloid beta-peptide inhibits Na+-dependent glutamate uptake - Lauderback_1999_Life.Sci_65_1977
Author(s) : Lauderback CM , Harris-White ME , Wang Y , Pedigo NW, Jr. , Carney JM , Butterfield DA
Ref : Life Sciences , 65 :1977 , 1999
Abstract :

The purpose of this review is to summarize much of the work on the inhibition of the astroglial glutamate transporter in relation to excitotoxic neurodegeneration, in particular, inhibition of uptake by the beta-amyloid peptide (A beta) found in the Alzheimer's disease (AD) brain. There is evidence for oxidative stress in the AD brain, and A beta has been found to generate reactive oxygen species (ROS), thus adding to the stress or possibly initiating it. The oxidative inhibition of the glutamate transporter protein by A beta increases the vulnerability of glutamatergic neurons, and by rendering them susceptible to the excitotoxic insult that results from impaired glutamate uptake, A beta can be directly connected to the neurodegeneration that follows.

PubMedSearch : Lauderback_1999_Life.Sci_65_1977
PubMedID: 10576449

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Citations formats

Lauderback CM, Harris-White ME, Wang Y, Pedigo NW, Jr., Carney JM, Butterfield DA (1999)
Amyloid beta-peptide inhibits Na+-dependent glutamate uptake
Life Sciences 65 :1977

Lauderback CM, Harris-White ME, Wang Y, Pedigo NW, Jr., Carney JM, Butterfield DA (1999)
Life Sciences 65 :1977