Layer_1995_Alzheimer.Dis.Assoc.Disord_2_29

Reference

Title : Nonclassical roles of cholinesterases in the embryonic brain and possible links to Alzheimer disease - Layer_1995_Alzheimer.Dis.Assoc.Disord_2_29
Author(s) : Layer PG
Ref : Alzheimer Disease & Associated Disorders , 2 :29 , 1995
Abstract :

Evidence about nonclassic functions of acetyl- (AChE) and butyryl-cholinesterase (BChE) during embryonic development of vertebrate brains is compared with evidence of their expression in Alzheimer disease (AD). Before axons extend in the early neural tube, BChE expression shortly precedes the expression of AChE. BChE is associated with neuronal and glial cell proliferation, and it may also regulate AChE. AChE is suggested to guide and stabilize growing axons. Pathologically, cholinesterase expression in AD shows some resemblance to that in the embryo. These findings are inconsistent with the "cholinergic hypothesis." Rather, it is suggested that cholinesterases in AD function nonclassically as in the embryo, possibly as part of a "neoembryonic" restorative program. These views may open new strategies for pharmacology and therapy for AD.

PubMedSearch : Layer_1995_Alzheimer.Dis.Assoc.Disord_2_29
PubMedID: 8534420

Related information

Citations formats

Layer PG (1995)
Nonclassical roles of cholinesterases in the embryonic brain and possible links to Alzheimer disease
Alzheimer Disease & Associated Disorders 2 :29

Layer PG (1995)
Alzheimer Disease & Associated Disorders 2 :29