Le Couteur_2012_Australas.J.Ageing_31_164

Reference

Title : Adherence, persistence and continuation with cholinesterase inhibitors in Alzheimer's disease - Le Couteur_2012_Australas.J.Ageing_31_164
Author(s) : Le Couteur DG , Robinson M , Leverton A , Creasey H , Waite L , Atkins K , McLachlan AJ
Ref : Australas J Ageing , 31 :164 , 2012
Abstract :

AIM: To determine adherence, persistence and continuation beyond 6 months with cholinesterase inhibitors in Australians with Alzheimer's disease. METHODS: Adherence and persistence with cholinesterase inhibitors were assessed by data linkage using the Pharmaceutical Benefits Scheme (PBS) Authority database and other health databases. RESULTS: Over 18 000 people commenced cholinesterase inhibitors during 2004. Adherence was 79.4% while the medication possession ratio was 0.88. Some 70.3% of people filled all six scripts for the initial trial period of therapy. Some 57.3% of evaluable patients accessed funding beyond six prescriptions, indicating that their clinicians had declared that there was a two-point or more greater improvement in the Mini-Mental State Examination. Despite the high rate of continuation beyond 6 months, the rates of institutionalisation and death were no different to those reported in clinical trials. CONCLUSIONS: Persistence and adherence with cholinesterase inhibitors was reasonable once treatment was established. There was an unexpectedly high continuation rate beyond six prescriptions.

PubMedSearch : Le Couteur_2012_Australas.J.Ageing_31_164
PubMedID: 22950587

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Citations formats

Le Couteur DG, Robinson M, Leverton A, Creasey H, Waite L, Atkins K, McLachlan AJ (2012)
Adherence, persistence and continuation with cholinesterase inhibitors in Alzheimer's disease
Australas J Ageing 31 :164

Le Couteur DG, Robinson M, Leverton A, Creasey H, Waite L, Atkins K, McLachlan AJ (2012)
Australas J Ageing 31 :164