| Title : In vitro metabolism of the new insecticide flupyrazofos by rat liver microsomes - Lee_1997_Xenobiotica_27_423 |
| Author(s) : Lee HS , Jeong S , Kim K , Kim JH , Lee SK , Kang BH , Roh JK |
| Ref : Xenobiotica , 27 :423 , 1997 |
| Abstract : 1. The in vitro metabolism of the new insecticide flupyrazofos was studied using rat liver microsomes. Two metabolites were produced and identified as O,O-diethyl O-(1-phenyl-3-trifluoromethyl-5-pyrazoyl) phosphoric acid ester (flupyrazofos oxon) and 1-phenyl-3-trifluoromethyl-5-hydroxypyrazole (PTMHP) based on UV and mass spectral analysis. 2. Cytochrome P450 oxidatively converted flupyrazofos to flupyrazofos oxon, a major metabolite and phenobarbital-induced microsomes increased this desulphuration by 8-fold. 3. Flupyrazofos oxon was converted to PTMHP with a half-life of 47.8 min by chemical hydrolysis and this conversion also proceeded non-enzymatically under our microsomal incubation conditions. |
| ESTHER : Lee_1997_Xenobiotica_27_423 |
| PubMedSearch : Lee_1997_Xenobiotica_27_423 |
| PubMedID: 9179985 |
Lee HS, Jeong S, Kim K, Kim JH, Lee SK, Kang BH, Roh JK (1997)
In vitro metabolism of the new insecticide flupyrazofos by rat liver microsomes
Xenobiotica
27 :423
Lee HS, Jeong S, Kim K, Kim JH, Lee SK, Kang BH, Roh JK (1997)
Xenobiotica
27 :423