| Title : Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel - Lee_2004_Arch.Pharm.Res_27_53 |
| Author(s) : Lee JH , Lee KT , Yang JH , Baek NI , Kim DK |
| Ref : Arch Pharm Res , 27 :53 , 2004 |
|
Abstract :
In the course of finding Korean natural products with acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the twigs of Vaccinium oldhami significantly inhibited AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two compounds, taraxerol (1) and scopoletin (2), as active constituents. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds 1 and 2 were 33.6 (79 microM) and 10.0 (52 microM) microg/mL, respectively. |
| PubMedSearch : Lee_2004_Arch.Pharm.Res_27_53 |
| PubMedID: 14969339 |
Lee JH, Lee KT, Yang JH, Baek NI, Kim DK (2004)
Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel
Arch Pharm Res
27 :53
Lee JH, Lee KT, Yang JH, Baek NI, Kim DK (2004)
Arch Pharm Res
27 :53