Lee_2009_Arch.Pharm.Res_32_677

Reference

Title : Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice - Lee_2009_Arch.Pharm.Res_32_677
Author(s) : Lee KY , Sung SH , Kim SH , Jang YP , Oh TH , Kim YC
Ref : Arch Pharm Res , 32 :677 , 2009
Abstract :

We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.

PubMedSearch : Lee_2009_Arch.Pharm.Res_32_677
PubMedID: 19471881

Related information

Citations formats

Lee KY, Sung SH, Kim SH, Jang YP, Oh TH, Kim YC (2009)
Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice
Arch Pharm Res 32 :677

Lee KY, Sung SH, Kim SH, Jang YP, Oh TH, Kim YC (2009)
Arch Pharm Res 32 :677