| Title : Anti-Acetylcholinesterase Alkaloids from Annona glabra Leaf - Lee_2015_Nat.Prod.Commun_10_891 |
| Author(s) : Lee SS , Wu DY , Tsai SF , Chen CK |
| Ref : Nat Prod Commun , 10 :891 , 2015 |
|
Abstract :
Bioassay guided fractionation and separation of the EtOH extract of Annona glabra leaf against acetylcholinesterse led to the characterization of 15 alkaloids. Among them, (-)-actinodaphnine (2) and (-)-(6aS,7R)-7-hydroxyactinodaphnine (9) are new aporphines, although (+)-2 and (+/-)-2 have been found in several plants. Their structures were established by spectroscopic analysis. (-)-Anolobine (5) and (-)-roemeroline (8) showed moderate inhibitory activity against eel acetylcholinesterase with IC50 values of 22.4 and 26.3 muM, respectively. |
| PubMedSearch : Lee_2015_Nat.Prod.Commun_10_891 |
| PubMedID: 26197510 |
Lee SS, Wu DY, Tsai SF, Chen CK (2015)
Anti-Acetylcholinesterase Alkaloids from Annona glabra Leaf
Nat Prod Commun
10 :891
Lee SS, Wu DY, Tsai SF, Chen CK (2015)
Nat Prod Commun
10 :891