Leelaja_2013_Ecotoxicol.Environ.Saf_94_8

Reference

Title : Biochemical and physiological responses in Caenorhabditis elegans exposed to sublethal concentrations of the organophosphorus insecticide, monocrotophos - Leelaja_2013_Ecotoxicol.Environ.Saf_94_8
Author(s) : Leelaja BC , Rajini PS
Ref : Ecotoxicology & Environmental Safety , 94 :8 , 2013
Abstract :

The objective of this study was to investigate the impact of sublethal concentrations of MCP on definitive markers of toxicity and oxidative balance in the nematode, Caenorhabditis elegans. Exposure of worms to 0.85, 1.7 and 3.4mM (1/40, 1/20 and 1/10 LC50; LC50=34 mM) for 4h at 20 degrees C induced significant perturbations in physiological parameters such as decreased brood size (47-73%), increased paralysis (47-85%) and inhibition of the activities of acetylcholinesterase (75-86%) and carboxylesterase (76-81%). These changes were accompanied by distinct oxidative impairments as evidenced by increased reactive oxygen species, decline in glutathione content and decrease in superoxide dismutase activity. Our results clearly demonstrate that low concentrations of MCP may alter the physiological and biochemical status in the nematode, thereby affecting the organism's fitness. Our findings on C. elegans provide an easy diagnosis for OPI contamination and may become helpful in evaluating the ecotoxicological effects of OPI in the aquatic environment near agricultural fields.

PubMedSearch : Leelaja_2013_Ecotoxicol.Environ.Saf_94_8
PubMedID: 23683899

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Citations formats

Leelaja BC, Rajini PS (2013)
Biochemical and physiological responses in Caenorhabditis elegans exposed to sublethal concentrations of the organophosphorus insecticide, monocrotophos
Ecotoxicology & Environmental Safety 94 :8

Leelaja BC, Rajini PS (2013)
Ecotoxicology & Environmental Safety 94 :8