| Title : Synthesis and preliminary in vivo evaluation of new 2-Aryl-6-methyl-1,2-dihydro-1H-pyridin-4-ones and 2-Aryl-6-methylpiperidin-4-ols, as potential anti-amnesiant agents - Leflemme_2005_J.Enzyme.Inhib.Med.Chem_20_551 |
| Author(s) : Leflemme N , Freret T , Boulouard M , Dallemagne P , Rault S |
| Ref : J Enzyme Inhib Med Chem , 20 :551 , 2005 |
|
Abstract :
A revisited synthesis of 2-aryl-6-methyl-1,2-dihydro-1H-pyridin-4-ones and their saturated analogues 2-aryl-6-methylpiperidin-4-ols is described. A five steps procedure, using the sulfinimine chemistry, to prepare a key intermediate beta-(6-chloronicotinic)-beta-amino ester is also reported. In vivo spontaneous working memory activity of these compounds has been investigated in the mouse. Results obtained with 2-(3-chlorophenyl)-6-methyl-1,2-dihydro-1H-pyridin-4-one 9b, the most effective derivative in this model, have been reported. |
| PubMedSearch : Leflemme_2005_J.Enzyme.Inhib.Med.Chem_20_551 |
| PubMedID: 16408790 |
Leflemme N, Freret T, Boulouard M, Dallemagne P, Rault S (2005)
Synthesis and preliminary in vivo evaluation of new 2-Aryl-6-methyl-1,2-dihydro-1H-pyridin-4-ones and 2-Aryl-6-methylpiperidin-4-ols, as potential anti-amnesiant agents
J Enzyme Inhib Med Chem
20 :551
Leflemme N, Freret T, Boulouard M, Dallemagne P, Rault S (2005)
J Enzyme Inhib Med Chem
20 :551