| Title : Clinical impact of [(18)F]flutemetamol PET among memory clinic patients with an unclear diagnosis - Leuzy_2019_Eur.J.Nucl.Med.Mol.Imaging_46_1276 |
| Author(s) : Leuzy A , Savitcheva I , Chiotis K , Lilja J , Andersen P , Bogdanovic N , Jelic V , Nordberg A |
| Ref : Eur J Nucl Med Mol Imaging , 46 :1276 , 2019 |
| Abstract : PURPOSE: To investigate the impact of amyloid PET with [(18)F]flutemetamol on diagnosis and treatment management in a cohort of patients attending a tertiary memory clinic in whom, despite extensive cognitive assessment including neuropsychological testing, structural imaging, CSF biomarker analysis and in some cases [(18)F]FDG PET, the diagnosis remained unclear. METHODS: The study population consisted of 207 patients with a clinical diagnosis prior to [(18)F]flutemetamol PET including mild cognitive impairment (MCI; n = 131), Alzheimer's disease (AD; n = 41), non-AD (n = 10), dementia not otherwise specified (dementia NOS; n = 20) and subjective cognitive decline (SCD; n = 5). RESULTS: Amyloid positivity was found in 53% of MCI, 68% of AD, 20% of non-AD, 20% of dementia NOS, and 60% of SCD patients. [(18)F]Flutemetamol PET led, overall, to a change in diagnosis in 92 of the 207 patients (44%). A high percentage of patients with a change in diagnosis was observed in the MCI group (n = 67, 51%) and in the dementia NOS group (n = 11; 55%), followed by the non-AD and AD (30% and 20%, respectively). A significant increase in cholinesterase inhibitor treatment was observed after [(18)F]flutemetamol PET (+218%, 34 patients before and 108 patients after). CONCLUSION: The present study lends support to the clinical value of amyloid PET in patients with an uncertain diagnosis in the tertiary memory clinic setting. |
| ESTHER : Leuzy_2019_Eur.J.Nucl.Med.Mol.Imaging_46_1276 |
| PubMedSearch : Leuzy_2019_Eur.J.Nucl.Med.Mol.Imaging_46_1276 |
| PubMedID: 30915522 |
Leuzy A, Savitcheva I, Chiotis K, Lilja J, Andersen P, Bogdanovic N, Jelic V, Nordberg A (2019)
Clinical impact of [(18)F]flutemetamol PET among memory clinic patients with an unclear diagnosis
Eur J Nucl Med Mol Imaging
46 :1276
Leuzy A, Savitcheva I, Chiotis K, Lilja J, Andersen P, Bogdanovic N, Jelic V, Nordberg A (2019)
Eur J Nucl Med Mol Imaging
46 :1276