| Title : Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1-->\;q13.2 - Levitt_1995_Cytogenet.Cell.Genet_69_211 |
| Author(s) : Levitt RC , Liu Z , Nouri N , Meyers DA , Brandriff B , Mohrenweiser HM |
| Ref : Cytogenet Cell Genet , 69 :211 , 1995 |
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Abstract :
Free fatty acids are the major source of fuel for mammals, and hormone sensitive lipase (LIPE) plays a critical role in lipid metabolism by mobilizing free fatty acids from stored triglycerides. We have identified and sequenced a partial cDNA for LIPE. Cosmids were identified by hybridization and mapped to 19q13.1-->q13.2 by FISH. Direct sequence analysis of a 1 kb segment of cosmid 26710 identifies a dinucleotide repeat in an intron upstream of exon 8 of human LIPE. This marker was heterozygous 82% of the time with 12 alleles (166-190 bp) detected in 122 chromosomes. The most likely order for this gene is: qter-[D19S178/LIPE]-(3 cM)-D19S47-(1 cM)-D19S190-RYR1-cen. |
| PubMedSearch : Levitt_1995_Cytogenet.Cell.Genet_69_211 |
| PubMedID: 7698015 |
Levitt RC, Liu Z, Nouri N, Meyers DA, Brandriff B, Mohrenweiser HM (1995)
Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1-->\;q13.2
Cytogenet Cell Genet
69 :211
Levitt RC, Liu Z, Nouri N, Meyers DA, Brandriff B, Mohrenweiser HM (1995)
Cytogenet Cell Genet
69 :211