Li_1998_Toxicol.Lett_98_139

Reference

Title : Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells - Li_1998_Toxicol.Lett_98_139
Author(s) : Li W , Casida JE
Ref : Toxicol Lett , 98 :139 , 1998
Abstract : This study compares two direct-acting neuropathy target esterase (NTE) inhibitors (mipafox and 2-octyl-4H-1,3,2-benzodioxophosphorin 2-oxide (OBDPO)), a metabolic precursor to an NTE inhibitor (tri-o-cresyl phosphate or TOCP) and a potent acetylcholinesterase inhibitor (chlorpyrifos oxon or CPO) for their effects on outgrowth of neurite-like and cell processes and on viability in differentiated cultured cells (rat adrenal pheochromocytoma (PC-12) and brain glial tumor (C6)). The direct-acting NTE inhibitors block process outgrowth by 50% or more at 50-100 microM for OBDPO and 100-200 microM for mipafox, well below their cytotoxic levels (EC50 values, 445-474 microM for OBDPO and 1021-1613 microM for mipafox). In contrast, the effects on process development for TOCP and CPO parallel their cytotoxicity. These findings suggest that inhibition of neurite-like and cell process outgrowth by OBDPO and mipafox may be associated with NTE inhibition.
ESTHER : Li_1998_Toxicol.Lett_98_139
PubMedSearch : Li_1998_Toxicol.Lett_98_139
PubMedID: 9788582

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Citations formats

Li W, Casida JE (1998)
Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells
Toxicol Lett 98 :139

Li W, Casida JE (1998)
Toxicol Lett 98 :139