| Title : Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine - Li_2006_Neuroreport_17_471 |
| Author(s) : Li W , Lee NT , Fu H , Kan KK , Pang Y , Li M , Tsim KWK , Li X , Han Y |
| Ref : Neuroreport , 17 :471 , 2006 |
| Abstract : Here we report that bis(7)-tacrine, a novel acetylcholinesterase inhibitor, exerts neuroprotective effects by inhibition of nitric oxide synthase. In cortical neurons at 12 days in vitro, bis(7)-tacrine concentration-dependently reduced cell death induced by glutamate, beta-amyloid and L-arginine, but not by nitric sodium nitroprusside. N-monomethyl-L-arginine, a nitric oxide synthase inhibitor, also prevented the former three types but not the last type of the cytotoxicity; however, nitric oxide scavengers blocked all of these insults, indicating that nitric oxide mediated these neuronal injuries. Furthermore, with nitric oxide synthase activity assays, it was found that bis(7)-tacrine not only suppressed the activation of nitric oxide synthase caused by glutamate in cortical neurons, but also directly inhibited the activity of nitric oxide synthase in vitro. |
| ESTHER : Li_2006_Neuroreport_17_471 |
| PubMedSearch : Li_2006_Neuroreport_17_471 |
| PubMedID: 16543809 |
Li W, Lee NT, Fu H, Kan KK, Pang Y, Li M, Tsim KWK, Li X, Han Y (2006)
Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine
Neuroreport
17 :471
Li W, Lee NT, Fu H, Kan KK, Pang Y, Li M, Tsim KWK, Li X, Han Y (2006)
Neuroreport
17 :471