Li_2009_Neuron_61_527

Reference

Title : Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation - Li_2009_Neuron_61_527
Author(s) : Li HL , Huang BS , Vishwasrao H , Sutedja N , Chen W , Jin I , Hawkins RD , Bailey CH , Kandel ER
Ref : Neuron , 61 :527 , 2009
Abstract :

Transsynaptic interactions between neurons are essential during both developmental and learning-related synaptic growth. We have used Aplysia neuronal cultures to examine the contribution of transsynaptic signals in both types of synapse formation. We find that during de novo synaptogenesis, specific presynaptic innervation is required for the clustering of postsynaptic AMPA-like but not NMDA-like receptors. We further find that the cell adhesion molecule Dscam is involved in these transsynaptic interactions. Inhibition of Dscam either pre- or postsynaptically abolishes the emergence of synaptic transmission and the clustering of AMPA-like receptors. Remodeling of both AMPA-like and NMDA-like receptors also occurs during learning-related synapse formation and again requires the reactivation of Dscam-mediated transsynaptic interactions. Taken together, these findings suggest that learning-induced synapse formation recapitulates, at least in part, aspects of the mechanisms that govern de novo synaptogenesis.

PubMedSearch : Li_2009_Neuron_61_527
PubMedID: 19249274

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Citations formats

Li HL, Huang BS, Vishwasrao H, Sutedja N, Chen W, Jin I, Hawkins RD, Bailey CH, Kandel ER (2009)
Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation
Neuron 61 :527

Li HL, Huang BS, Vishwasrao H, Sutedja N, Chen W, Jin I, Hawkins RD, Bailey CH, Kandel ER (2009)
Neuron 61 :527