| Title : Acetylcholinesterase inhibitory dimeric indole derivatives from the marine actinomycetes Rubrobacter radiotolerans - Li_2015_Fitoterapia_102_203 |
| Author(s) : Li JL , Huang L , Liu J , Song Y , Gao J , Jung JH , Liu Y , Chen G |
| Ref : Fitoterapia , 102 :203 , 2015 |
|
Abstract :
Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute configurations were assigned by CD calculations. The acetylcholinesterase (AchE) inhibitory activity of compounds 1 and 2 was evaluated, both of which showed moderate activity with IC50 values of 11.8 and 13.5muM, respectively. |
| PubMedSearch : Li_2015_Fitoterapia_102_203 |
| PubMedID: 25655350 |
Li JL, Huang L, Liu J, Song Y, Gao J, Jung JH, Liu Y, Chen G (2015)
Acetylcholinesterase inhibitory dimeric indole derivatives from the marine actinomycetes Rubrobacter radiotolerans
Fitoterapia
102 :203
Li JL, Huang L, Liu J, Song Y, Gao J, Jung JH, Liu Y, Chen G (2015)
Fitoterapia
102 :203